with Dr.Ing. Adrian Fulga of APTM SA
APTM SA is a leading supplier of micronizers, ultra-fine prowder equipment
and total process containment technologies. We currently deliver grinding,
mixing and handling equipment and assist customers in the processing
industries, particularly in the chemical and pharmaceutical sectors,
with the design, development, construction and optimization of individual
APTM offers its customers a wide range of services in all areas of technological
development and implementation, project management and process consulting
and validation. We adapt flexibly to the starting point of each customer
from development of individual process steps to comprehensive
optimization and validation of entire powder manufacturing processes.
The main offices and laboratories are located in Lugano-Stabio, Switzerland.
In addition, the company runs a branch (APTM Srl) in Italy.
APTM was formed by the acquisition and restructuring of the former Arescom
SA to build up its strength in the field of micronization engineering
for the chemical and pharmaceutical industries. For more information
see company's presentation.
APTM work with powders?
APTM has various technology groups, which operate all kinds of powder
production steps. One of these groups is the solids processing group.
This handles all solids processing steps such as drying, crystallization,
sieving, sifting, milling, micronization, dedusting and solids handling.
The activities of the group cover process development, optimization
of existing production plants and sample provision (of new and modified
is Adrian Fulga?
I am the technical director of APTM, member of the solids processing
group and head of R&D and engineering department. Our team has 5
With the help of our experimental equipment we can undertake all kinds
of research and investigations. In addition, we have a complete infrastructure
for solids and powder handling. To design processes involving solids
it is necessary to carry out many experimental works. This applies to
all kinds of products, whether chemicals, pharmaceuticals, cosmetics
is APTM equipped for R&D works?
We have been using our 4" and 8" SuperJet and StarJet micronisers
for many years now.
They are installed in a special, GMP isolator for the micronization
of drug substances. These materials are very valuable and it is important
to reach the desired particle size as fast as possible. The processing
isolator is connected to a special analysing glovebox that holds all
measuring equipment to obtain the result of the milling without any
delay. Thus we can react and adjust the micronising parameters very
Both isolators has been designed to cleanroom requirements. With this
system, we achieve our aim of running the microniser so that it meets
the specification all the time. No product is lost because the particle
size misses the specification. We control and document the micronizing
process continually. That is very important in terms of GMP.
Using the total process containment technology, we save a lot of time
and money because the correct milling parameters are found very quickly.
This is extremely important because in our case the product very often
varies. The yield of the micronizer was increased. We no longer have
the problem of products missing the specification. These pharmaceutical
products are very valuable so each gram saved is a real gain. In short,
we can perform much better in a sector where high quality is crucial.